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Shingles Vaccine Decreases Alzheimer’s Risk

A nice side benefit to something we should do, anyway.

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The Economist‘s double-clickbait headline “A no-brainer for protecting your brain: One simple vaccination may dramatically reduce the risk of dementia” did its job. I learned something surprising.

Recent studies point out the numerous ways in which people are already reducing their risk of dementia. Many are lifestyle changes that you already know you should be making, such as eating healthily, exercising more and keeping your brain active. Others are medical interventions, such as treating hearing loss, depression, high blood pressure and high cholesterol. But getting people to adopt, and then stick to, healthy habits is hard. It does not help that, ideally, you should be working out more and boozing less for many years before your brain will thank you.

Tell me about it.

Yet there is one direct way to improve your chances of staying mentally sharp, and it involves almost no toil, tears or sweat. One of the most exciting scientific findings in recent years is that a course of the shingles vaccine may reduce the risk of dementia by about 20%. For a simple intervention, that is a huge benefit. Exactly why this happens is still being debated. One theory is that the varicella-zoster virus, which causes both shingles and chickenpox, contributes to dementia by causing damage or inflammation to the nervous system even while it is supposedly dormant. Another is that the vaccination gives the immune system a firm kick up its B-cells, activating it against other bugs that might contribute to dementia.

My wife and I both got the shots a couple of years back to, well, reduce the risk of getting shingles, which is a horrible disease in its own right. I had no idea until this morning that it seems to help ward off an even worse disease.

Here in the States, the vaccine is recommended for those over 50 and is widely covered by insurance. Oddly, this is not the case across the Pond.

Too many public-health systems fail to offer the vaccine to more than just a small share of those who would benefit. Several studies have shown that, taking into account only the shingles cases prevented, it would be cost-effective to vaccinate almost everyone from about the age of 55. Yet many countries have rationed the vaccine to keep down the upfront costs. Britain, for instance, lowered the eligibility age from 70 to 65 in 2023, but has since been too slow to vaccinate those who were already in their late 60s. Among the 27 members of the European Union, just 17 recommend the vaccine at all, and several reserve it for the over-65s.

That makes little sense when considering only its efficacy against shingles, which afflicts 20-30% of unvaccinated people. It makes even less sense given its potential as a weapon in the fight against dementia.

Indeed. Of course, with universal health coverage, cost-benefit calculations have to be made. And the vaccine is more expensive than I would have guessed (it was free to me under my insurance).

A full two-dose course of Shingrix costs Britain’s health service £320 ($430) and federal immunisation programmes in America around $270: a bargain, given the potential savings in long-term care costs. As for individuals, even the retail cost (around £460 in Britain) is a small price to reduce by one-fifth the chances of having the world recede in every direction.

One would think.

10 responses to “Shingles Vaccine Decreases Alzheimer’s Risk”

  1. This link has been observed for a while now, but unless you spend a lot of time in health care/policy discussions, the general public might have missed it.

    After watching my father and uncle really, really suffer with shingles (my uncle had shingles that spread into his eyes), I got the vaccination series as soon as I was eligible.

    I am curious as to how this will affect younger people, who were vaccinated against chicken pox and have never had that–do they then need the shingles vaccination, or not?

    1. Jen @Jen I had chickenpox as a kid, but was still advised to get the Shingrix sequence.

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      1. Yes–me too. If you’ve had the chicken pox, the virus that can cause shingles exists in your system–that’s why it is so important to get the shingles vaccine.

        What I am curious about is the reverse. The kids who receive the chicken pox vaccine presumably are far less likely to get the chicken pox, and therefore will not have the virus circulating in their system. So, do they need the shingles vaccine? Or no?

        1. IMO, the risk from vaccines are so low and the benefits so high, it’s best to take the vaccine.

  2. Are you sure this isn’t just Big Pharma propaganda?

    I heard that if I just use beef tallow to fry my potatoes, I will live to 112.

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    1. Just avoid seed oils, you’ll be fine. /s

  3. As the proud possessor of a double dose of the APOE4 allele, this is good news to me. Dementia is my greatest aging fear. I have had my shingles shots so all the better. I’m 72 but have not had any signs yet. There are tests coming into the market to measure an Alzheimer’s biomarker pTau217 so at least detection may be close and getting better.

    Fingers crossed.

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  4. Its not really clear if its a direct effect of the vaccine or a secondary effect from avoiding a painful, sometimes debilitating illness. There is literature showing that painful injuries/illnesses can cause or accelerate cognitive dysfunction.

    Steve

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    1. And that should provide further motivation for an eligible person to get the vaccine.

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